The Dog Aging Project has two components a large-scale, longitudinal study of ageing in pet dogs, and a Rapamycin intervention trial.
The first phase of the Rapamycin trial has finished. The second phase intends to enrol a larger group of middle-aged healthy dogs into a long-term, low-dose Rapamycin regimen.
http://dogagingproject.com/rapamycin-intervention-trial/
http://veterinarynews.dvm360.com/rapamycin-real-fountain-youth
https://www.researchgate.net/profile/Silvan_Urfer/publication/304555702_The_Dog_Aging_Project_Rapamycin_as_a_Potential_Aging_Modulator_in_Dogs/links/57735bbd08aeef01a0b666e9.pdf?origin=publication_detail
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The summary given is -
“The key findings are that there were no significant side effects associated with the rapamycin treatment, and there were statistically significant improvements in heart function in the dogs that received rapamycin relative to those that received the placebo, similar to what has been observed in older laboratory mice.”
But it doesn’t say how much longer it extends lifespan of the dogs. I’m wondering if this is mostly for dogs that would have heart issues?
MajorMajor, thanks for posting. The phase two trial study form states “There are no restrictions on breed of dog for the phase 2 study. Dogs must be at least 6 years old, 40 pounds in weight minimum and in good health, without significant pre-existing conditions”
Based on laboratory studies, we anticipate that this regimen of rapamycin treatment could improve healthy longevity of typical pet dogs by 2-5 years. Whether there are in fact dogs with heart issues, actually on the trial I do not know.
The article below also states dogs have to be healthy and over 40 pounds.
http://edition.cnn.com/2016/10/06/health/rapamycin-dog-live-longer/index.html
Phase 2 of the Dog Aging Project (Rapamycin Intervention trial) is due to start soon.
http://bettybarks.com/phase-2-finally/
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A further article on The Dog Aging Project. https://www.leafscience.org/dr-matt-kaeberlein-the-dog-aging-project/
A talk by Dr. Matt Kaeberlein of The Dog Aging Project. The talk leads up to the Dog Aging Project which starts at 14 min.
Next Generation Medicine: Dr. Matt Kaeberlein on Dogs & the Science of Human Aging. https://www.youtube.com/watch?v=2tIGSkzElf0
https://dogagingproject.org/
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Dog Aging Project takes veterinary research in new direction. https://news.vin.com/VINNews.aspx?articleId=54979
Grant launches Dog Aging Project biobank at Cornell. https://news.cornell.edu/stories/2020/07/grant-launches-dog-aging-project-biobank-cornell
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What is your dog’s lifespan? A Princeton geneticist is seeking the keys to canine health and longevity.
https://www.princeton.edu/news/2022/02/02/what-your-dogs-lifespan-you-might-be-surprised
Thank you for sharing this link Seaweed.
There seems to be a current acceptance of a variety of variables that influence longevity in dogs. I’m thinking the size of dogs ie larger vs smaller dogs; and the narrower gene pools used in breeding pedigree dogs ie pedigree vs mixed breed; whether altering hormones ie neutering/spaying may influence lifespan, etc.
Regardless of patterns of longevity indicated by variables, I’d expect non-genetically-inherited ill health to be a variable which could skew the expected outcomes, as could nurture, environment, accidents and bad luck.
It would be great to have a definitive answer, or at least a more accurate idea of what to expect! We may then be able to actively help dogs live longer, healthier, happier lives.